How PROTIVA works

We begin with the protein you want to produce, your cell type and the expression system you use. Together, we define what you want to improve and the reference design against which candidates will be evaluated.

This gives the programme a practical target, whether the priority is protein output or understanding which promoter designs perform best in that context.

Promoters help control when a gene is read and how strongly it is expressed. PROTIVA explores promoter designs suited to your molecule, production cells and expression system.

The gene encoding the protein remains unchanged. The designs focus on its surrounding regulatory instructions.

Selected sequences are made and tested in the intended cells. In a CHO evaluation, candidate expression constructs are compared with a reference while keeping the gene of interest and test conditions consistent.

Measured expression and protein output help identify which promoter designs merit further testing. Those results also inform the next round of sequence design.

We review the results with your team against the agreed evaluation criteria. That determines whether to refine the designs, carry out additional testing or move towards licensing successful sequences for your programme.